Abstract: Based on the long-term continuous hydro-meteorological data from buoys and tidal gauge stations in the upper Pearl River Estuary near Guangzhou, the hydro-meteorological characteristics of this region during the Typhoons Hato and Mangkhut are analyzed, and the dynamic factors causing the marine disasters are also discussed. Results show that firstly influenced by typhoon the wind speed of each station increased from Level 1-4 to 7-8, and the wind speed reached the maximum around 6-7 hours influenced by Typhoon Level 7 wind circle. The tide levels of all station are above the red warning tide level. The maximum storm surge is approximately 2-3 meters. The wave height increased from Level 1-2 to 3-4. The residual current decreased before it increased. The lowest value of the residual current appeared on the day of the typhoon landfall and the typhoon changes the direction of the residual current. The sea surface temperature dropped by 1-2 ℃ and the sea surface salinity increased by 4-12. Secondly, the first response to the typhoon were wind and residual current. The maximum wave height appeared about 1 hour later than the maximum wind speed. The highest tide level appeared in about 1-2 hours later than the typhoon landfall. The changes in sea surface temperature and salinity came later than the wind in about 5-6 hours. Thirdly, the typhoon wind circle radius, the duration of the severe typhoon, typhoon intensity and the moving speed had a great influence on storm surge and wave disaster. The wave height increased sharply and it also had a great influence on the storm surge with correlation coefficient of about 0.7. Fourthly, the landing position of Mangkhut was 74 km farther than Hato, and it was not in the astronomical spring tide period, but the level 7 wind circle radius was 130 km larger than that of Hato. The duration of the severe typhoon was 27 hours longer than that of Hato, so the marine disaster caused by Mangkhut was stronger than Hato. Also, the maximum storm surge was 30-50 cm higher than that of Hato. The Level II storm surge lasted 2.5 hours longer than Hato, and the moderate wave lasted 11 hours longer than that of Hato.