Abstract: The spatiotemporal variations of temperature inversion in the Gulf of Alaska (GOA) are analyzed based on 2002-2020 Argo data and relationship between its interannual variations and vertical potential temperature anomaly also is investigated. The results show that there are considerable spatiotemporal variations of temperature inversion. Spatially, temperature difference (ΔT) is the largest, moderate and the weakest in the northern GOA (NGOA), southeastern GOA (SEGOA) and southwest (SWGOA), respectively. The inversion thickness (ΔD) is the thickest in the SWGOA, relatively thinner in the NGOA and thinnest in the SEGOA. As for seasonal change, ΔT and ΔD in the NGOA change apparently with the largest ΔT and ΔD in winter, then they decrease because of seasonal heating and vertical mixing. In the SEGOA, ΔT peaks in March (0.46 ℃) and September (0.40 ℃). There has a ΔD maximum (44 m) in winter and a ΔD minimum (only 23 m) in autumn. In the SWGOA, ΔT changes with seasonal alternations in 0.24-0.33 ℃ producing two peaks 0.31 and 0.33 ℃ in April and October, respectively. ΔD is larger than 100 m in winter and is the thinnest about 57 m in autumn. At interannual time scales, ΔT displayed positive anomalies in 2002, 2007-2009, 2012 and 2017, but negative anomalies in 2003-2005, 2010, 2013-2016 and 2018-2020. ΔD is mainly thicker than normal in 2002, 2007-2008, 2012 and 2017-2020, while thinner than normal in 2003-2006 and 2015-2016. The interannual variations of ΔT and ΔD in the NGOA and SEGOA are well consistent with each other, but there is no clear connection between them in the SWGOA. Moreover, ΔT and ΔDchanges are closely related to vertical potential temperature anomaly. When the vertical potential temperature of seawater was in cold (warm) anomaly, ΔT revealed a positive (negative) anomaly in the whole GOA, ΔD tended to be thicker (thinner) in the NGOA and SEGOA , but thinner (thicker) in the SWGOA.