Abstract: Fc receptors (FcRs) are a class of receptor that specifically binds to the Fc segment of immunoglobulin and mediates a variety of immune responses. In this study, six FcR genes were cloned from large yellow croaker (Larimichthys crocea), including LcFcγRⅠL, LcFcγRⅡ, LcFcγRⅡaL, LcFcγRⅢ, LcFcRL5 and LcFcRLA, and their open reading frame is 1 070, 2 486, 1 145, 1 955, 4 125 and 1 659 base pair, respectively. Each of LcFcRs contains a signal peptide and 2-8 Ig domains, and LcFcγRⅡ, LcFcγRⅢ and LcFcRL5 also contain a transmembrane region. Expression prolife analysis showed that LcFcγRⅠL, LcFcγRⅡ, LcFcγRⅡaL and LcFcγRⅢ were mainly expressed in mucous tissues such as gill or intestine, while LcFcRL5 and LcFcRLA were mainly expressed in immune tissues such as spleen and head kidney. Moreover, upon LPS the expression of these six FcRs genes in the spleen and head kidney was significantly up-regulated at different time points. After stimulation with poly (I:C) challenged, the six FcRs genes were significantly up-regulated in head kidney and spleen at different time points, whereas the expression of LcFcRL5 was significantly up-regulated in the spleen but significantly down-regulated in the head kidney. Results reveal that large yellow croaker FcRs may play different important roles in the immune response induced by LPS and poly (I:C).