Abstract: In this study, extracts of two species of soft coral Sinularia were prepared by methanol, and tested for the sunscreen activity by absorption of different UV range, the whitening activity by the tyrosinase inhibition, and the antioxidant activity by measurement of DPPH. The potential application of the natural substances from soft corals in cosmetics development was investigated for the first time. The results showed that extracts of Sinularia compacta and Sinularia wanannensis exhibited a strong absorption of UV. As the concentration increased, the absorption band of the extracts from S. compacta and S. wanannensis expanded, with high absorption of UV from 280-400 nm at concentrations above 5.0 mg/cm3. Generally the sunscreen activity of the extract from S. compacta was better than that of the extract from S. wanannensis. Both the extracts showed higher absorption of UV than the positive controls of arbutin and benzophenone. Besides, the UV absorption of the extract from S. compacta at 10.0 mg/cm3 was comparable to that of the positive control of rutin, indicating the high sunscreen activities of the extracts from two species of soft corals. The extracts of two species showed similar inhibitory activities against tyrosinase. Furthermore, both the extracts showed outstanding antioxidant activities. Their antioxidant activities increased with increasing concentrations. The extracts of two species at 1.0-5.0 mg/cm3 showed comparable antioxidant activities to the positive control of Vc. The extract from S. wanannensis at 10.0 mg/cm3 exhibited significantly higher antioxidant activity than the extract of S. compacta and Vc. The results are important to develop novel natural cosmetics derived from soft corals.