Abstract: Based on the temperature, salinity and the climate data on the South Yellow Sea section of August from 1977 to 2016, the climate response and spatio-temporal modes on the interannual variation of summer temperature and salinity were studied statistically. The results showed that the interannual variation of temperature can be divided into 4 spatio-temporal modes. The wind-driven current, the strength and area of the cold water mass in summer and the temperature modes on the cross section in winter are the main factors affecting the interannual variation of the main temperature modes. The wind-driven current field in summer, the spring PDOindex and temperature modes in winter section are the main factors affecting the interannual temperature variation in the secondary mode. The temporal component of the temperature mode is always a long periodic interannual variation in a quasi-equilibrium state. The interannual variation of salinity can be divided into 4 spatio-temporal modes. The low salinity water in northern Jiangsu coastal sea and the high salinity water in the Southern Yellow Sea and the wind-driven current transport effect in the Yellow Sea in summer are the main factors affecting the salinity mode of interannual variation. The decreased summer precipitation and the attenuated winddriven current transfer in the Southern Yellow Sea are the main factors affecting the interannual variation of salinity in the secondary mode. The temporal component of the main salinity mode shows a long periodic interannual variation in a quasi-equilibrium state. The secondary salinity mode decreases linearly and significantly with interannual variation. The seasonal multi-year mean temperature and salinity distribution are mainly influenced by the wind-driven circulation in summer. The monthly mean temperature of the core cold water mass in the South Yellow Sea shows an interannual variation in a quasi-equilibrium state, and the area is in a remarkable trend of linear decreasing. The seasonal and interannual variations of the winddriven current fields are the main factors affecting the interannual variation of the intensity and range of the core cold water mass in the South Yellow Sea. The spring PDOindex has a significant nonlinear effect on the interannual variation of the area of cold water mass. The monthly mean salinities of cold water mass and core cold water mass on the South Yellow Sea section are characterized by significant interannual variation with linear low salinity trend. Compared the situation more than 30 years ago, the temporal and spatial variation of the seasonal temperature and salinity field cycle in the Yellow Sea may have changed significantly due to a long period of linear trend of temperature and salinity variations there.